Är ingen expert men hittade lite fakta om dosering med Olanzapin.
"Our review suggests that the likelihood of a favorable response with olanzapine is maximized at doses of 10 to 15 mg/d (perhaps lower in nonsmoking females). Higher doses may be considered if 15 mg is ineffective and if plasma level is less than 20 ng/mL on that dose. There is a direct linear relationship between olanzapine dose and plasma concentration. Therapeutic drug monitoring may be useful in patients who are suspected of nonadherence, where there is potential for a drug interaction, and in patients taking 15 mg/d or more and who have not reached clinical response."
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pubmed.ncbi.nlm.nih.gov/23609380/
"It has been reported that a favourable response with olanzapine is maximised at doses of 10 mg/day to 15 mg/day (perhaps lower in nonsmoking females) (Bishara 2013). However, lower or higher doses may be used and the relationship between olanzapine dose, efficacy and side effects remains contradictory between studies. The impact of olanzapine on quality of life for people with schizophrenia was not important at low doses (2.5 mg/day to 10 mg/day) but important improvements were observed at medium doses (10 mg/day to 20 mg/day) and high doses (more than 20 mg/day) (Bobes 2007). Olanzapine at high doses of 30 mg/day and 40 mg/day displayed pharmacokinetic and tolerance profiles consistent with that of 20 mg/day, however, akathisia (inability to stay still or restlessness) may be more likely to occur at these higher doses (Mitchell 2006; Kinon 2008)."
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www.ncbi.nlm.nih.gov/pmc/articles/PMC6373521/
Det är nog väldigt individuellt hur en person reagerar på olika doser av ett läkemedel som Olanzapin.
