Emil Kraepelin kom med namnet dementia praecox (förtida demens) 1899 innan schizofreni kom lite senare.
Med hjälp av bildbehandling och maskininlärning, har forskare hittat de första giltiga indikationerna på neuroanatomiska mönster i hjärnan vid schizofreni som liknar signaturen hos patienter med frontotemporal demens.
Det är ovanligt att 120 år gamla forskningsresultat undersöks på nytt.
Frontotemporal demens förväxlas ofta med schizofreni.
41 % av de med schizofreni verkade ha beteende varianten av frontotemporal demens.
Läs mer hos Neuroscience.
In summary,74 we identified specific overlaps between macroscopic brain signatures of schizophrenia and bvFTD. These overlaps mediated aspects of the clinical-behavioral heterogeneity of both conditions, ie, a negative avolitional syndrome in the former, and a potentially neuroinflammation-associated phenotype involving neurocognitive dysfunction in the latterFinally, our study revealed that young patients with poor functional outcomes overexpressed these brain patterns over time, in line with Kraepelin’s concept of dementia praecox as a progressive frontotemporal disorder. Further studies into molecular disease pathways are needed to clarify how different pathophysiological processes project on overlapping neural alterations in bvFTD and schizophrenia-spectrum disorders.
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2794930
https://lakartidningen.se/wp-content/uploads/OldWebArticlePdf/1/12024/LKT0920s1381_1385.pdf